Reward deficiency and anti-reward in pain chronification

Reward deficiency and anti-reward in pain chronification

Converging lines of evidence suggest that the pathophysiology of pain is mediated to a substantial degree via allostatic neuroadaptations in reward- and stress-related brain circuits. Thus, reward deficiency (RD) represents a within-system neuroadaptation to pain-induced protracted activation of the reward circuits that leads to depletion-like hypodopaminergia, clinically manifested anhedonia, ...

Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems.

Anhedonia is a condition that leads to the loss of feelings pleasure in response to natural reinforcers like food, sex, exercise, and social activities. This disorder occurs in addiction, and an array of related neuropsychiatric syndromes, including schizophrenia, depression, and Post Traumatic Stress Disorder (PTSD). Anhedonia may by due to derangements in mesolimbic dopaminergic pathways and ...

Asymptotic Behavior of Multivariate Reward Processes with Nonlinear Reward Functions

What's deficient in reward deficiency?

It has been proposed that people with substance use disorders suffer from a reward deficiency syndrome. Sometimes this is framed as a pre-existing trait; sometimes it is framed as an acquired condition. Although the reward deficiency idea is often used as an explanation for excessive substance use, there is little consensus about the deficiency's basis or how it might increase drug and alcohol ...

COVARIANCE MATRIX OF MULTIVARIATE REWARD PROCESSES WITH NONLINEAR REWARD FUNCTIONS

Multivariate reward processes with reward functions of constant rates, defined on a semi-Markov process, first were studied by Masuda and Sumita, 1991. Reward processes with nonlinear reward functions were introduced in Soltani, 1996. In this work we study a multivariate process , , where are reward processes with nonlinear reward functions respectively. The Laplace transform of the covar...